PURINA® PRO PLAN® VETERINARY DIETS CC CardioCare™ is a complete dietetic pet food for adult dogs containing an advanced blend of nutrients (Cardiac Protection Blend - CPB) proven to support cardiac function and delay the progresion of heart disease from the early stages.
- Medium-Chain Triglycerides (MCTs) oil as an alternative energy source for the myocytes
- Key amino acids (L-Lysine, Methionine) precursors of carnitine, a crucial transporter for fatty acids to get into mitochondria
- Fish oil (Omega-3 fatty acids) to help reduce inflammation
- Vitamin E to help prevent oxidative cell damage
- Magnesium which binds ATP to deliver energy to the cardiac cells
- Taurine to help maintain heart contractile function
Heart murmurs are turbulences in the blood flow that create a distinguishable sound during the heart auscultation.
Heart murmurs can be common in young dogs, and although they often subside with age, they can also be an early sign of heart disease.
There are 3 types of heart murmurs and each type can be graded on a scale of 1 to 6 depending on the severity.
- It is characterised by a slowly progressive mitral valve degeneration associated with alterations in energy metabolism, oxidative stress, inflammation, and in advanced stages, heart enlargement1.
- In the early stages, dogs show no outward signs of disease and are considered as clinically normal.
- Strong evidence supports that adapting the diet at this early stage will help delay clinical signs2.
1Borgarelli M, Haggstrom J. Canine degenerative myxomatous mitral valve disease: Natural history, clinical presentation and therapy. Vet Clin North Am Small Anim Pract 2010;40: 651–663.
2Li Q, Heaney A, et al. Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomized controlled study in 36 dogs. BMC Veterinary Research. 2019; 15:425.
PURINA® PRO PLAN®
VETERINARY DIETS CC CardioCare™
is supported by science
Dietary intervention can help slow progression and heart enlargement in dogs within early stages of myxomatous mitral valve disease (MMVD). (Li et al., 2019)*
- The study evaluated the clinical impact of a diet formulated with a cardiac protection blend (CPB) designed to address metabolic alterations, and progression of naturally occurring early preclinical stage of MMVD in dogs.
- Results showed that a blend of nutrients, designed to address metabolic changes associated with MMVD in dogs, was able to slow or reverse cardiac changes within early and preclinical stage of the MMVD disease.
*Li Q, Heaney A, et al. Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomised controlled study in 36 dogs. BMC Veterinary Research. 2019; 15:425.
Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs (Li et al., 2015)*.
- The study characterised molecular and metabolic pathways that might play a role in the pathogenesis and progression of MMVD, by applying metabolomics and transcriptomics techniques.
- Results showed that dogs with MMVD presented altered energy metabolism in cardiac tissues, as well as an increase in markers of oxidative stress.
- Many of the observed disturbances may benefit from nutritional or medical management, but additional research is needed.
*Li Q, Heaney A, et al. Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs. OMICS A Journal of Integrative Biology. 2015; 19:8.
Serum untargeted metabolomic changes in response to diet intervention in dogs with preclinical myxomatous mitral valve disease (Li et al., 2020)*.
- The study evaluated a cardiac protection blend (CPB) of nutrients in a 6-month dietary intervention to investigate changes in the metabolism of certain components.
- Numerous metabolites were identified reflecting improved cardiac bioenergetics and fatty acid utilization by cardiac mitochondria in dogs fed the CPB diet.
- Metabolomic markers also suggest improved cellular redox state and reduced inflammation in MMVD dogs fed the CPB diet.
*Li Q, Laflamme DP, Bauer JE (2020) Serum untargeted metabolomic changes in response to diet intervention in dogs with preclinical myxomatous mitral valve disease. PLoS ONE 15(6): e0234404.